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Sulfur-containing phosphonate monomers for oligonucleotide synthesis
Kostov, Ondřej ; Zborníková, Eva ; Buděšínský, Miloš ; Novák, Pavel ; Rosenberg, Ivan
A series of novel compounds, protected S-MOP nucleoside-5’-O-methylphosphonothioates, was prepared as monomers for solid phase synthesis of phosphonothioate oligonucleotides. In addition we have examined the synthetic potential of nucleoside-5’-O-methyl-(H)-phosphinates for phosphonate oligonucleotide assembly.

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